The PS3's full power channeled into making you feel old alongside Snake. "Old Snake" opens with this exhausted, worn-down theme that tells you immediately: this is an ending. The "Love Theme" carries so much weight from the entire series it almost buckles under it.
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Then there's "Guns of the Patriots" itself, pulling together decades of narrative threads into one devastating composition. Between the combat tension of "Desperate Chase" and the quiet devastation of "Father & Son," this soundtrack covers enormous emotional range.
"Here's to You" closing things out... yeah. The whole score sounds like a soldier's last debrief. If you finished MGS4 and didn't cry, listen to this alone in the dark and try again.