George Alistair Sanger went absolutely feral on this score and it still holds up. The 7th Guest's Come Back! reissue brings back that early-CD-ROM haunted mansion atmosphere where every room has its own unsettling personality.
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The Story of Stauf sets the mood with this creepy carnival quality that never fully lets go. Music Box does exactly what you think but somehow worse, in the best way. Coffin Dance goes from eerie to frantic in a way that perfectly mirrors scrambling through that puzzle.
Basement Maze really does feel lonely. Chapel Theme carries this strange beauty that almost makes you forget something horrible is about to happen. If you played this in the 90s and still remember Stauf's laugh, the music is why.