Ridley Hertz absolutely unloaded on the Repentance score. The Binding of Isaac already had a killer soundtrack but these new floors hit different. Carrion is this suffocating wall of distorted bass and choir samples that makes the Corpse biome feel genuinely oppressive.
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Then you get to Stargazer and it's suddenly this gorgeous ambient piece that has no business being in a game about a crying naked child fighting poop. The way Morticide builds during the Hush fight is honestly panic-inducing.
Walls of Denial goes full industrial and it works so well against Mausoleum's crumbling gothic tiles. That Genesis Retake Dark closer though. If you've been putting off the final completion marks, this soundtrack alone justifies the suffering.